SaintSkinny:
I'd like to start making up some Temp and RH data loggers to sell, since having this information in an indoor garden (or lots of other situations) can be invaluable in a lot of cases, but many growers don't have finances to go buy a pre-built logger,
I find that rather difficult to believe. I severely doubt you could even construct one for $20 (US), let alone cheaper!

SaintSkinny:
Would there be any real downside to swapping out the UNO for a Micro or Nano?
Virtually none.
SaintSkinny:
I built my data logger with an UNO R3 (a clone I think, Elegoo) and it worked fine. I started with the UNO bc it seemed to be the most popular. Now that I've worked with the board and learned more about the other boards, and seeing that they're much more similar than I thought, I'm considering using a different board for the model I sell.
I figured that if the Nano/Micro were cheaper, yet can do the job as well as the UNO, it's a no brainer!
Well, I suppose the UNO is more heavily marketed by the Arduino project, but really it is only for experimental or demonstration use, except perhaps where a particular shield allows it to perform the whole of your application. For actual "real world" applications, the Nano is the most appropriate.
Nick_Pyner:
A Nano is just a stripped-down UNO so no problem, but it may be a half-baked approach, in that they are still development devices.
What a curious suggestion! 
In what respect is it "stripped-down"? The only difference is the use of a dedicated-purpose USB bridge rather than the 16U2 in the UNO, but it is rare indeed for anyone to actually utilise the secondary processor. A Nano is electrically almost identical to a Duemilanove.
Nick_Pyner:
If you are serious about some sort of mass production, you might look at using the guts of the UNO on a custom PCB, or maybe a similar MCU in a simpler package.
It would have to be mass production - in the thousands - to justify the cost of inventory to customise the Nano itself. Far more practical to use Nanos (albeit "clones") as daughterboards to your custom PCB, generally cheaper and easier assembly.
Paul_KD7HB:
Be sure to leave access to the USB connector so you can replace the program when bugs are discovered.
Well, if you did not want the USB function, you would be using a Pro Mini. In this particular case, it is the download portal - though removing a SD card is another approach.
wkdkris:
As above if you want to make some sort of product, I'd seriously think about having a custom PCB made, with the required components of the Nano, and whatever other components you need. It would be a lot more reliable in the long run for day to day use.
Just how do you imagine it would be more reliable? 
wkdkris:
To answer your question, there's no real downside, except less pins. But if you don't need them, it doesn't matter does it
Less pins? Do you actually know what a Nano is? (Hint: The Pro Mini/ Nano has two extra, analog input only, pins compared to the UNO.)