The handle is invalid

So, I just received a MEGA 2560 in a starter kit, and I have gone through the set up and still cannot upload a program to the board. Any suggestions?

Error Message.PNG

What does Windows Device Manager show?

(deleted)

What OS, too?

If 1.6.8 on Windows, don't use that version, it has a bug, use 1.6.5r5 or 1.6.9.

If on Linux/Mac - does your user account have permission to open serial ports?