Upload to Nano fails: "avrdude: ser_open(): can't set com-state for"

Which probably means that Windows updated the driver again. I did write a slightly different approach in Sudden Issue: BSODs on 4 Different Laptops Using Arduino Mega (CH341) in Classroom Today (First Time in 3 Months) - #13 by sterretje.

Once you followed those steps and you connected the board, Windows will update to the latest driver that it knows about (and does not work for you). But you can now roll back the driver (I did forget to mention that in that topic) and tell Windows that the current driver does not work on your current system.

To check which drivers are available you can click the update driver button as described in the linked post, select Let me pick from a list of available drivers on my computer; in the linked post there are three (don't ask me why), I currently have two.

You can roll back using the roll back button in the first image. Windows will ask you why you want to roll back. Tick the appropriate option and click Yes.

Windows will have rolled back the driver and should no longer update it automatically.

PS
The 2022/01/18 is the driver that I gave you earlier.