I want to know, because I programed (not professional, just academic) C, Java, VB 6 and C#.
But, this first time Im programing with Hardware (GUI Interface). And still hard to understand. I know for example, in C make a GUI and conection with a lot of things (joystick, camera and etc) its hard. But if you use VB.net is more easy to make a GUI interface. But, again, you will have prons and cons in every program. 
How I said, Im new, and I wanted to listen some people have more experience in GUI interface... 
Thanks in advance!