That circuit is just part of what looks like a UNO . Where is your circuit ? , what have you wired reset too ? Is just for a coms port or are you to program via it ? Where are the connections to the processor and power supply ?
Decoupling caps appear to be missing, they are not optional. These caps must be as close to the chip as possible.
Doublecheck value of loading caps on crystal. Traces to the crystal must be kept as short as possible.
The resistors on the TX and RX lines are too low value, they will load the serial lines, I would use 1k min, preferably 2.2k. (though this is not the problem you're seeing)
What do you see in device manager?
Have you doublechecked connections? Particularly on the USB connector, if it's mini/micro - very easy to get solder bridges here.
Those are all the problems I encountered with my CH340G boards iirc. Also, post the layout - you can't ignore layout considerations here.