Trouble uploading sketch with Mac OS X 10.8.5 - sudden failure.

Summary:
I was running and uploading programs successfully to Uno board. No issues - all good.

Then, I received the following error:

avrdude: stk500_recv(): programmer is not responding.

I tried several reset combinations, etc (per the troubleshooting guidelines) with no success. I also tried uploading a basic sketch to a different UNO board with no success (same cable), same error message.

Hardware:
Mac OS X 10.8.5
New Uno Boards

Any Ideas?