ESP-01 ESP8266 connection error: "Failed to connect to ESP8266: Timed out waiting for packet header"

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Sounds like you encountered the same issue I was, here is the thread where it was fixed:

ESP-01S on Arduino MEGA 2560 - A fatal esptool.py error occurred: Failed to connect to ESP8266: Timed out waiting for packet header

Hi! I've been trying to make an ESP-01S work with an Arduino MEGA 2560 for 3 days now, reading countless threads and guides without success. The equipment: Controllers: ESP-01S: https://www.amazon.ca/dp/B00O34AGSU?psc=1&ref=ppx_yo2ov_dt_b_product_details Arduino MEGA 2560 R3: https://www.amazon.ca/dp/B01H4ZLZLQ?psc=1&ref=ppx_yo2ov_dt_b_product_details LF33CV: https://www.mouser.ca/ProductDetail/STMicroelectronics/LF33CV?qs=LPKLnBpMevjK%252B28MZYQO9Q%3D%3D Power supply 5V60A: https://w…

Good luck!