After uploading to an S3 board the board must be power cycled to make it
run the code that was just uploaded. I now use the S3 connected to a USB hub with a
power button for each port. Using the power button is much easier than
unplugging and plugging the USB cable. IDE 1.8.19.
Oh thank you @ oldcurmudgeon for the hint, I had the same problem with my board's ( ESP32 S3 DevKitC1 clone) RGB led, and was looking for a simple way to turn it on and choose the colour (simple way >> no need to load a library like Adafruit Neopixel).
It works like a charm !