I've recently had problems with a serial port not showing up on my MacBook Pro running the latest rev of macOS High Sierra. After much investigation, it appears to be a bug in Apple's own AppleUSBACM (Version 5.0.0) driver/kext. Here are the details and two workarounds as I reported to Apple's support forum:
Well i just downloaded the Serial app and it indeed does something to view the serial port and it connects fine and receives data from the arduino nano i have plugged into it because i can see the data in the terminal screen of the Serial.app, but when i go over to the arduino ide the port is not there, so I cant really do anything else except see the response from the old sketch i had on that nano.
Ive rebooted the macbook pro 2x and still the arduino IDE doesnt see the port.
@mikew67 I am also having this issue and your Apple support link no longer exists - would appreciate if you could share the workarounds you found directly!