I'm not having any luck with this plugin. I am on a windows 11 machine with IDE2.2.1. Trying to upload to a generic ESP8266. I did the plugin install as shown on github, but it won't upload, giving the following output and error:
Building LittleFS filesystem
C:\Users\flagt\AppData\Local\Arduino15\packages\esp32\tools\mklittlefs\3.0.0-gnu12-dc7f933/mklittlefs.exe -c C:\Users\flagt\Documents\Arduino\greenhouseplay5-31/data -p 256 -b 8192 -s 2072576 C:\Users\flagt\AppData\Local\Temp\tmp-12324-Gb19XUlCX4pO-.littlefs.bin
/greenhouse.jpg
Uploading LittleFS filesystem
C:\Users\flagt\AppData\Local\Arduino15\packages\esp8266\tools\python3\3.7.2-post1/python3.exe C:\Users\flagt\AppData\Local\Arduino15\packages\esp8266\hardware\esp8266\3.1.2/tools/upload.py --chip esp8266 --port COM5 --baud 921600 write_flash 2097152 C:\Users\flagt\AppData\Local\Temp\tmp-12324-Gb19XUlCX4pO-.littlefs.bin
esptool.py v3.0
Serial port COM5
A fatal esptool.py error occurred: could not open port 'COM5': PermissionError(13, 'Access is denied.', None, 5)
Completed upload.
I followed instructions to change to another board and back; no help
Then close and open the sketch; no help. Not sure where to go from here. Sadly I have older projects that need updated files, but can't upload them 
When switching to another board (D1 mini) it appeared on Com6 in the ide as well as Device Manager. However I get this error when trying to upload to it:
Building LittleFS filesystem
C:\Users\flagt\AppData\Local\Arduino15\packages\esp32\tools\mklittlefs\3.0.0-gnu12-dc7f933/mklittlefs.exe -c C:\Users\flagt\Documents\Arduino\spiffs_test_program/data -p 256 -b 8192 -s 3121152 C:\Users\flagt\AppData\Local\Temp\tmp-17252-XRsWiYY9eTxD-.littlefs.bin
/Testing the Little FS system.txt
Uploading LittleFS filesystem
C:\Users\flagt\AppData\Local\Arduino15\packages\esp8266\tools\python3\3.7.2-post1/python3.exe C:\Users\flagt\AppData\Local\Arduino15\packages\esp8266\hardware\esp8266\3.1.2/tools/upload.py --chip esp8266 --port COM6 --baud 115200 write_flash 1048576 C:\Users\flagt\AppData\Local\Temp\tmp-17252-XRsWiYY9eTxD-.littlefs.bin
esptool.py v3.0
Serial port COM6
A fatal esptool.py error occurred: Cannot configure port, something went wrong. Original message: PermissionError(13, 'A device attached to the system is not functioning.', None, 31)
Completed upload.
and when closing the upload panel:
Port monitor error:command 'open' failed: invalid serial port. Could not connect to COM6 serial port.