Can I connect the ESP32-S3 to two computer ports?

I have a MAC and therefore through the COM port I receive information from the Serial Monitor, and on the other(port) I load the script, can I use them at the same time or will I damage the board?

Works no differently to a PC. I am on a Mac myself.

No you don't.
You receive it from the serial monitor, this is not a com port.

There is only one com port on an ESP32.

So I don't understand your question.

@Grumpy_Mike



When I connect to COM port, Serial Monitor starts working and when I connect to USB port, I can upload script

And I meant another port in my question(here - usb)

you can connect both

OK yes this is not what I was expecting because the ESP32-S3 can come in many forms, one of which is actually the nano ESP32.

Good luck.

No damage, you can try connecting both but it may not work.

Yes you can use both at the same time and it will not damage the board

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